tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Base Information

Chemical Name:tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate
CAS No.:370867-83-7
Molecular Formula:C₁₄H₁₇FO₂
Molecular Weight:236.286
Hs Code.:

Synonyms:tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Suppliers and Price of tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

There total 3 articles about tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 139911-27-6
4-fluoro-3-methylphenyl boronic acid

: 370867-83-7
tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; copper(II) sulfate; palladium dichloride; In water; at 85 ℃; for 10h; stereoselective reaction; Schlenk technique;
DOI:10.1055/s-0033-1339650

Reference yield:

: 27784-76-5
tert-butyl diethylphosphonoacetate

: 135427-08-6
4-fluoro-3-methylbenzaldehyde

: 370867-83-7
tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Guidance literature:: tert-butyl diethylphosphonoacetate; With sodium hexamethyldisilazane; In tetrahydrofuran; toluene; at 25 ℃; for 0.5h;

4-fluoro-3-methylbenzaldehyde; In tetrahydrofuran; toluene; at 20 ℃; Further stages.;
DOI:10.1021/jm010100v

Reference yield:

: 77771-02-9
3-bromo-4-fluorobenzaldehyde

: 370867-83-7
tert-butyl (E)-3-(3-fluoro-4-methylphenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: CsF; Pd(Ph₃P)4 / 1,2-dimethoxy-ethane / 17 h / Heating

2.1: NaHMDS / tetrahydrofuran; toluene / 0.5 h / 25 °C

2.2: tetrahydrofuran; toluene / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hexamethyldisilazane; cesium fluoride; In tetrahydrofuran; 1,2-dimethoxyethane; toluene; 2.2: Horner-Emmons reaction;
DOI:10.1021/jm010100v