(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

Base Information

Chemical Name:(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide
CAS No.:1632142-56-3
Molecular Formula:C₂₃H₂₉NO₃
Molecular Weight:367.488
Hs Code.:

Synonyms:(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

Chemical Property:

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Technology Process of (R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

There total 3 articles about (R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 1632142-55-2
C₁₉H₂₂O₃

: 1632142-56-3
(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

Guidance literature:: In para-xylene; at 20 ℃; for 0.5h; enantiospecific reaction; Reflux;
DOI:10.1055/s-0033-1341059

Reference yield:

: 4463-33-6
1,2-dimethoxy-3-methylbenzene

: 1632142-56-3
(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium / hexane; pentane / 3 h / 20 °C

1.2: 1 h / -78 - 20 °C

2.1: triethylamine; bis{(μ-hydroxy)bis(triphenylphosphine)palladium(II)} tetrafluoroborate / 1,4-dioxane; water / 1.5 h / 80 °C

3.1: para-xylene / 0.5 h / 20 °C / Reflux

With bis{(μ-hydroxy)bis(triphenylphosphine)palladium(II)} tetrafluoroborate; N,N,N,N,-tetramethylethylenediamine; tert.-butyl lithium; triethylamine; In 1,4-dioxane; hexane; para-xylene; water; pentane; 3.1: |Eschenmoser-Claisen Rearrangement;
DOI:10.1055/s-0033-1341059

Reference yield:

: 1632142-54-1
(2,3-dimethoxy-4-methylphenyl)boronic acid

: 1632142-56-3
(R,E)-3-(2,3-dimethoxy-4-methylphenyl)-N,N,3-trimethyl-5-phenylpent-4-enamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis{(μ-hydroxy)bis(triphenylphosphine)palladium(II)} tetrafluoroborate / 1,4-dioxane; water / 1.5 h / 80 °C

2: para-xylene / 0.5 h / 20 °C / Reflux

With bis{(μ-hydroxy)bis(triphenylphosphine)palladium(II)} tetrafluoroborate; triethylamine; In 1,4-dioxane; para-xylene; water; 2: |Eschenmoser-Claisen Rearrangement;
DOI:10.1055/s-0033-1341059