N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide

Base Information

• Chemical Name: N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide
• CAS No.: 1174271-61-4
• Molecular Formula: C₁₃H₁₁F₃N₄S
• Molecular Weight: 312.318
• Mol file: 1174271-61-4.mol

Synonyms:N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide

Chemical Property of N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide

There total 1 articles about N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.2%

pyrid-2-ylhydrazine (4930-98-7) + 4-(trifluoromethyl)phenyl isothiocyanate (1645-65-4) → N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide (1174271-61-4)

Guidance literature:

In acetonitrile; at 100 ℃; for 0.666667h; Microwave irradiation;

DOI:10.1039/c2ce26718g

Reference yield: 72.0%

N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide (1174271-61-4) → N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine (1174271-66-9)

Guidance literature:

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; solid phase reaction;

DOI:10.1021/jo9009084

Reference yield: 30.0%

zinc(II) nitrate (10196-18-6) + N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide (1174271-61-4) → C26H20F6N8S2Zn (1433159-63-7)

Guidance literature:

In acetonitrile; for 16h; Reflux;

DOI:10.1039/c2ce26718g

upstream raw materials:

pyrid-2-ylhydrazine

4-(trifluoromethyl)phenyl isothiocyanate

Downstream raw materials:

N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

CF₃O₃S^(1-)*C₁₈H₁₃F₃N₅⁽¹⁺⁾

C₂₆H₂₀F₆N₈S₂Zn