N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

Base Information

• Chemical Name: N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine
• CAS No.: 1174271-66-9
• Molecular Formula: C₁₃H₉F₃N₄
• Molecular Weight: 278.236
• Mol file: 1174271-66-9.mol

Synonyms:N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

Chemical Property of N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine

There total 3 articles about N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

pyrid-2-ylhydrazine (4930-98-7) + 4-(trifluoromethyl)phenyl isothiocyanate (1645-65-4) → N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine (1174271-66-9)

Guidance literature:

With iodine; In water; at 20 ℃; for 3h; Green chemistry;

DOI:10.1021/acs.joc.8b00753

Reference yield: 72.0%

N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide (1174271-61-4) → N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine (1174271-66-9)

Guidance literature:

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In tetrahydrofuran; at 20 ℃; solid phase reaction;

DOI:10.1021/jo9009084

Reference yield:

CF3O3S(1-)*C19H16ClNOPol(1+) + N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide (1174271-61-4) → N-(4-(trifluoromethyl)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-3-amine (1174271-66-9) + CF3O3S(1-)*C18H13F3N5(1+) (1174271-77-2)

Guidance literature:

CF₃O₃S^(1-)*C₁₉H₁₆ClNOPol⁽¹⁺⁾; N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; at 5 ℃; for 21h; solid phase reaction;

With methanol; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo9009084

upstream raw materials:

N-(4-trifluoromethylphenyl)-2-pyridin-2-ylhydrazinecarbothioamide

pyrid-2-ylhydrazine

4-(trifluoromethyl)phenyl isothiocyanate