5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione

Base Information

• Chemical Name: 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione
• CAS No.: 628686-92-0
• Molecular Formula: C₁₇H₁₆N₂O₅
• Molecular Weight: 328.324
• Mol file: 628686-92-0.mol

Synonyms:5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione

Chemical Property of 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione

There total 5 articles about 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-amino-4,6-dimethoxybenzoic acid (21577-57-1) + 4-methoxybenzoyl isocyanate (4695-57-2) → 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione (628686-92-0)

Guidance literature:

silica gel; In ethanol; ethyl acetate;

Reference yield: 59.0%

4-Methoxyphenyl isocyanate (5416-93-3) + methyl 2-amino-4,6-dimethoxybenzoate (379228-26-9) → 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione (628686-92-0)

Guidance literature:

4-Methoxyphenyl isocyanate; methyl 2-amino-4,6-dimethoxybenzoate; With 4 A molecular sieve; In ethyl acetate; for 1h; Heating;

With hydrogenchloride; In ethanol; for 2h; Heating;

DOI:10.1021/jm0509389

Reference yield:

2-amino-4,6-dimethoxybenzoic acid (21577-57-1) → 5,7-dimethoxy-3-(4-methoxyphenyl)-2,4-(1H,3H)-quinazolinedione (628686-92-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrahydrofuran; methanol / 20 °C

2.1: 4 Angstroem molecular sieves / ethyl acetate / 1 h / Heating

2.2: 59 percent / HCl(g) / ethanol / 2 h / Heating

With 4 A molecular sieve; In tetrahydrofuran; methanol; ethyl acetate;

DOI:10.1021/jm0509389

upstream raw materials:

4-Methoxyphenyl isocyanate

methyl 2-amino-4,6-dimethoxybenzoate

4,6-dimethoxyindoline-2,3-dione

2-amino-4,6-dimethoxybenzoic acid