1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone

Base Information

• Chemical Name: 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone
• CAS No.: 1313481-15-0
• Molecular Formula: C₂₆H₂₅ClN₄O₂
• Molecular Weight: 460.963

Synonyms:1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone

Chemical Property of 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone

Chemical Property:

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Technology Process of 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone

There total 3 articles about 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,9-dichloro-2-methoxyacridine (86-38-4) + 1-acetyl-4-(4-aminophenyl)piperazine (92394-00-8) → 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone (1313481-15-0)

Guidance literature:

6,9-dichloro-2-methoxyacridine; 1-acetyl-4-(4-aminophenyl)piperazine; With hydrogenchloride; In ethanol; water; for 24h; Reflux;

In ethanol; water; Alkaline conditions;

DOI:10.1016/j.ejmech.2011.04.016

Reference yield:

p-nitrobenzene iodide (636-98-6) → 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone (1313481-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / 2585.81 Torr

3.1: hydrogenchloride / ethanol; water / 24 h / Reflux

3.2: Alkaline conditions

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene; 1.1: Hartwig-Buchwald reaction;

DOI:10.1016/j.ejmech.2011.04.016

Reference yield:

N-acetylpiperidine (13889-98-0) → 1-(4-(4-(6-chloro-2-methoxyacridin-9-ylamino)phenyl)piperazin-1-yl)ethanone (1313481-15-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / 2585.81 Torr

3.1: hydrogenchloride / ethanol; water / 24 h / Reflux

3.2: Alkaline conditions

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In ethanol; water; toluene; 1.1: Hartwig-Buchwald reaction;

DOI:10.1016/j.ejmech.2011.04.016

upstream raw materials:

p-nitrobenzene iodide

N-acetylpiperidine

6,9-dichloro-2-methoxyacridine

1-acetyl-4-(4-aminophenyl)piperazine

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