benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

Base Information

Chemical Name:benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate
CAS No.:1644598-73-1
Molecular Formula:C₁₈H₁₇FN₂O₆
Molecular Weight:376.341
Hs Code.:

Synonyms:benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

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Chemical Property of benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

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Technology Process of benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

There total 3 articles about benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1309431-02-4
benzyl 2,6-difluoro-3-nitrobenzoate

: (R)-alanine methyl ester hydrochloride

: 1644598-73-1
benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

Guidance literature:: With caesium carbonate; at 85 ℃; for 13h;
DOI:10.1002/anie.201402750

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1644598-73-1
benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Microwave irradiation

1.2: 16.5 h / 20 - 110 °C

2.1: caesium carbonate / 13 h / 85 °C

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.201402750

Reference yield:

: 100-39-0
benzyl bromide

: 1644598-73-1
benzyl 6-fluoro-2-{[(2R)-1-methoxy-1-oxopropan-2-yl]amino}-3-nitrobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C / Microwave irradiation

1.2: 16.5 h / 20 - 110 °C

2.1: caesium carbonate / 13 h / 85 °C

With potassium carbonate; caesium carbonate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.201402750