2-Phenylhex-5-enoic acid

Base Information

Chemical Name:2-Phenylhex-5-enoic acid
CAS No.:156297-00-6
Molecular Formula:C₁₂H₁₄O₂
Molecular Weight:190.242
Hs Code.:
European Community (EC) Number:961-903-1

Synonyms:2-phenylhex-5-enoic acid;156297-00-6;2-phenylhex-5-enoicacid;SCHEMBL1363093;AKOS017532117;CS-0235039;EN300-152226;F2147-8853

Suppliers and Price of 2-Phenylhex-5-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 2-Phenylhex-5-enoic acid

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:190.099379685
Heavy Atom Count:14
Complexity:193

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C=CCCC(C1=CC=CC=C1)C(=O)O

Technology Process of 2-Phenylhex-5-enoic acid

There total 5 articles about 2-Phenylhex-5-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 177037-80-8
methyl 2-phenylhex-5-enoate

: 156297-00-6
2-phenylhex-5-enoic acid

Guidance literature:: With sodium hydroxide; In methanol; water; for 2h; Heating;
DOI:10.1135/cccc20071472

Reference yield: 75.0%

: 5162-44-7
1-bromo-4-butene

: 103-82-2
phenylacetic acid

: 156297-00-6
2-phenylhex-5-enoic acid

Guidance literature:: phenylacetic acid; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 0.75h; Inert atmosphere;

1-bromo-4-butene; In tetrahydrofuran; hexane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/acs.joc.8b00807

Reference yield:

: 83-13-6
diethyl 2-phenylmalonate

: 156297-00-6
2-phenylhex-5-enoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluorormethanesulfonic acid; potassium hydride / dimethyl sulfoxide / 12.25 h / 0 - 50 °C / Inert atmosphere

2.1: potassium hydroxide / ethanol; water / 6 h / Inert atmosphere; Reflux

2.2: pH 2 / Inert atmosphere

3.1: 14 h / 155 °C / Inert atmosphere

With trifluorormethanesulfonic acid; potassium hydride; potassium hydroxide; In ethanol; water; dimethyl sulfoxide;
DOI:10.1248/cpb.60.548