1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

Base Information

Chemical Name:1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine
CAS No.:99282-01-6
Molecular Formula:C₂₀H₂₅NO₅
Molecular Weight:359.422
Hs Code.:

Synonyms:1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

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Chemical Property of 1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

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Technology Process of 1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

There total 9 articles about 1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 99282-00-5
1-<(3,4,5-trimethoxyphenyl)methyl>-7,8-bis(benzyloxy)-2,3,4,5-tetrhydro-1H-2-benzazepine

: 99282-01-6
1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; under 2068.6 Torr; Ambient temperature;
DOI:10.1021/jm00152a003

Reference yield: 43.0%

: 99281-99-9
1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-(methylenedioxy)-2,3,4,5-tetrhydro-1H-2-benzazepine

: 99282-01-6
1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

Guidance literature:: With boron trichloride; In dichloromethane; for 5h; Ambient temperature;
DOI:10.1021/jm00152a003

Reference yield:

: 951-82-6
3,4,5-trimethoxyphenyl acetic acid

: 99282-01-6
1-[(3,4,5-trimethoxyphenyl)methyl]-7,8-dihydroxy-2,3,4,5-tetrhydro-1H-2-benzazepine

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / 72 h / Heating

2: POCl₃ / acetonitrile / 5 h / Heating

3: BH₃*THF / tetrahydrofuran / 9 h / Heating

4: 43 percent / BCl₃ / CH₂Cl₂ / 5 h / Ambient temperature

With borane-THF; boron trichloride; trichlorophosphate; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1021/jm00152a003