benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Base Information

Chemical Name:benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate
CAS No.:1417617-98-1
Molecular Formula:C₃₁H₂₆FN₃O₅
Molecular Weight:539.563
Hs Code.:

Synonyms:benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Suppliers and Price of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

There total 5 articles about benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 480449-99-8,128041-58-7
3-hydroxycyclobutylcarboxylic acid benzyl ester

: 1315457-42-1
4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

: 1417617-98-1
benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Guidance literature:: With triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 - 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 1315312-36-7
5-chloro-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine

: 1417617-98-1
benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 60 - 80 °C / Inert atmosphere

3.1: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With boron tribromide; sodium hydride; sodium hydrogencarbonate; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; mineral oil;

Reference yield:

: 1315312-37-8
4-(5-chloro-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenol

: 1417617-98-1
benzyl 3-{4-[5-(2-fluorophenoxy)oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethylphenoxy}cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

1.2: 16 h / 60 - 80 °C / Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate; triethylamine / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; N,N-dimethyl acetamide; mineral oil;