4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

Base Information

Chemical Name:4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol
CAS No.:1315457-42-1
Molecular Formula:C₁₉H₁₄FN₃O₃
Molecular Weight:351.337
Hs Code.:

Synonyms:4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

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Chemical Property of 4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

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Technology Process of 4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

There total 5 articles about 4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 367-12-4
2-fluorophenol

: 1315312-37-8
4-(5-chloro-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenol

: 1315457-42-1
4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

Guidance literature:: 2-fluorophenol; With sodium hydride; In N,N-dimethyl acetamide; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

4-(5-chloro-oxazolo[5,4-d]pyrimidin-2-yl)-2,6-dimethyl-phenol; In N,N-dimethyl acetamide; mineral oil; at 60 - 80 ℃; for 16h; Inert atmosphere;

Reference yield:

: 1315457-41-0
5-(2-fluoro-phenoxy)-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine

: 1315457-42-1
4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

Guidance literature:: 5-(2-fluoro-phenoxy)-2-(4-methoxy-3,5-dimethyl-phenyl)-oxazolo[5,4-d]pyrimidine; With boron tribromide; In dichloromethane; at 0 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 1315312-35-6
N-(2,4-dichloro-pyrimidin-5-yl)-4-methoxy-3,5-dimethyl-benzamide

: 1315457-42-1
4-[5-(2-fluoro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h / 160 °C / Microwave irradiation

2.1: boron tribromide; sodium hydrogencarbonate / dichloromethane / 2 h / 0 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl acetamide / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 60 - 80 °C / Inert atmosphere

With boron tribromide; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl acetamide; acetonitrile; mineral oil;