[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

Base Information

Chemical Name:[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]
CAS No.:1337905-66-4
Molecular Formula:C₃₃H₃₁N₅O₉
Molecular Weight:641.637
Hs Code.:

Synonyms:[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

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Chemical Property of [-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

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Technology Process of [-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

There total 7 articles about [-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 20069-09-4
piperlongumine

: 6146-52-7
5-nitroindole

: 1337905-65-3
[1-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one]

: 1337905-66-4
[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

Guidance literature:: With iodine; In 1,2-dichloro-ethane; for 12h; Reflux;

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1337905-65-3
[1-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one]

: 1337905-66-4
[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

Guidance literature:: Multi-step reaction with 5 steps

1.1: benzene / 3 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 12 h / 20 °C

3.1: triethylamine / tetrahydrofuran / 0.75 h / -20 °C

4.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

4.2: 1 h / -78 °C

5.1: iodine / 1,2-dichloro-ethane / 12 h / 80 °C

With n-butyllithium; water; iodine; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dichloro-ethane; benzene; 1.1: |Wittig Olefination / 5.1: |Michael Addition;
DOI:10.1016/j.ejmech.2012.09.014

Reference yield:

: C₁₇H₂₂O₆

: 1337905-65-3
[1-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-5,6-dihydropyridin-2(1H)-one]

: 1337905-66-4
[-(3-(3,4,5-trimethoxyphenyl)-3-(5-nitro-1H-indol-3-yl)propanoyl)-4-(5-nitro-1H-indol-3-yl)piperidin-2-one]

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 0.75 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C

2.1: iodine / 1,2-dichloro-ethane / 12 h / 80 °C

With n-butyllithium; iodine; In tetrahydrofuran; 1,2-dichloro-ethane; 2.1: |Michael Addition;
DOI:10.1016/j.ejmech.2012.09.014