Technology Process of N-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine
There total 9 articles about N-n-propyl-2-(4-fluoro-3-methoxyphenyl)ethylamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
lithium aluminium tetrahydride;
In
diethyl ether;
for 4h;
Ambient temperature;
DOI:10.1021/jm00171a014
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 70 percent / potassium permanganate, pyridine / H2O / 1.) 50 deg C, 3 h, 2.) RT, 3 h
2: 95 percent / LiAlH4 / diethyl ether / 3 h / Ambient temperature
3: 95 percent / pyridinium chlorochromate / CH2Cl2 / 2 h
4: 84 percent / Na2CO3, methylamine hydrochloride / ethanol / 72 h / Ambient temperature
5: 54 percent / LiAlH4 / tetrahydrofuran / 12 h / Ambient temperature
6: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
7: 87 percent / LiAlH4 / diethyl ether / 4 h / Ambient temperature
With
pyridine; potassium permanganate; lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/jm00171a014
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 84 percent / K2CO3 / acetone / 5 h / Heating
2: 70 percent / potassium permanganate, pyridine / H2O / 1.) 50 deg C, 3 h, 2.) RT, 3 h
3: 95 percent / LiAlH4 / diethyl ether / 3 h / Ambient temperature
4: 95 percent / pyridinium chlorochromate / CH2Cl2 / 2 h
5: 84 percent / Na2CO3, methylamine hydrochloride / ethanol / 72 h / Ambient temperature
6: 54 percent / LiAlH4 / tetrahydrofuran / 12 h / Ambient temperature
7: 82 percent / triethylamine / diethyl ether / 1 h / Ambient temperature
8: 87 percent / LiAlH4 / diethyl ether / 4 h / Ambient temperature
With
pyridine; potassium permanganate; lithium aluminium tetrahydride; methylamine hydrochloride; sodium carbonate; potassium carbonate; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1021/jm00171a014
