dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Base Information

Chemical Name:dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate
CAS No.:1395241-51-6
Molecular Formula:C₂₄H₁₉ClN₄O₅
Molecular Weight:478.892
Hs Code.:

Synonyms:dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

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Chemical Property of dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

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Technology Process of dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

There total 4 articles about dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 17630-76-1
5-chloroindole 2,3-dione

: 106-49-0,12221-03-3
p-toluidine

: 762-42-5
dimethyl acetylenedicarboxylate

: 109-77-3
malononitrile

: 1395241-51-6
dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Guidance literature:: With molybdenum complex on cross-linked poly(1-aminopropyl-3-vinylimidazolium bromide)entrapped cobalt oxide nanoparticles; In water; at 20 ℃; for 0.15h; regioselective reaction; Sonication;
DOI:10.1016/j.ultsonch.2021.105614

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1395241-51-6
dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.17 h / 20 °C

2: triethylamine / 24 h / Reflux

With triethylamine; In ethanol;
DOI:10.1002/cjoc.201100657

Reference yield:

: 762-42-5
dimethyl acetylenedicarboxylate

: 1395241-51-6
dimethyl 2'-amino-5-chloro-3'-cyano-2-oxo-1'-(p-tolyl)-1'H-spiro[indoline-3,4'-pyridine]-5',6'-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 0.17 h / 20 °C

2: triethylamine / 24 h / Reflux

With triethylamine; In ethanol;
DOI:10.1002/cjoc.201100657