Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

Base Information

Chemical Name:Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester
CAS No.:220094-48-4
Molecular Formula:C₂₇H₃₈ClNO₅Si
Molecular Weight:520.141
Hs Code.:

Synonyms:Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

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Chemical Property of Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

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Technology Process of Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

There total 5 articles about Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 33842-02-3,529510-96-1
dichloromethylenedimethyliminium chloride

: 220094-47-3
(2R,3S,4S,5R,6S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-6-methoxy-5-methyl-tetrahydro-pyran-3,4-diol

: 220094-48-4
Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

: Dimethyl-carbamic acid (2R,3S,4R,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: With triethylamine; In 1,2-dichloro-ethane; at 100 ℃; for 0.5h;
DOI:10.1055/s-1999-3671

Reference yield:

: 101978-79-4
Methyl 4,6-O-benzylidene-2-deoxy-2-C-methyl-α-D-allopyranoside

: 220094-48-4
Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

2: DMAP, NEt₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: 82 percent / Et₃N / 1,2-dichloro-ethane / 0.5 h / 100 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1055/s-1999-3671

Reference yield:

: 194149-26-3
methyl 2,3:4,6-di-O-benzylidene-α-D-mannopyranoside

: 220094-48-4
Dimethyl-carbamic acid (2R,3R,4S,5R,6S)-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-chloro-6-methoxy-5-methyl-tetrahydro-pyran-4-yl ester

Guidance literature:: Multi-step reaction with 4 steps

2: H₂ / 10percent Pd/C / ethyl acetate; ethanol / 1 h / Ambient temperature

3: DMAP, NEt₃ / CH₂Cl₂ / 2 h / Ambient temperature

4: 82 percent / Et₃N / 1,2-dichloro-ethane / 0.5 h / 100 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1055/s-1999-3671