1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

Base Information

• Chemical Name: 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate
• CAS No.: 1280226-44-9
• Molecular Formula: CF₃O₃S*C₁₇H₂₀NO₂
• Molecular Weight: 419.422
• Mol file: 1280226-44-9.mol

Synonyms:1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

Chemical Property of 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

There total 4 articles about 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

allyl triflate (41029-45-2) + 1-(4-methoxypyridin-2-yl)-2-phenylethanol (1280226-34-7) → 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate (1280226-44-9)

Guidance literature:

In dichloromethane; at -30 - 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol200478p

Reference yield:

4-methoxypyridine-2-carbaldehyde (16744-81-3) → 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate (1280226-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 4 h / -30 °C / Inert atmosphere

2.1: dichloromethane / 4 h / -30 - 0 °C / Inert atmosphere

With magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; 1.2: Grignard addition;

DOI:10.1021/ol200478p

Reference yield:

benzyl bromide (100-39-0) → 1-allyl-2-(1-hydroxy-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate (1280226-44-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: magnesium; ethylene dibromide / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 4 h / -30 °C / Inert atmosphere

2.1: dichloromethane / 4 h / -30 - 0 °C / Inert atmosphere

With magnesium; ethylene dibromide; In tetrahydrofuran; dichloromethane; 1.2: Grignard addition;

DOI:10.1021/ol200478p

upstream raw materials:

4-methoxypyridine-2-carbaldehyde

allyl triflate

1-(4-methoxypyridin-2-yl)-2-phenylethanol

benzyl bromide

Downstream raw materials:

1-allyl-2-(1-((di-tert-butylsilyl)oxy)-2-phenylethyl)-4-methoxypyridin-1-ium trifluoromethanesulfonate

Refernces