(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Base Information

Chemical Name:(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide
CAS No.:1067648-47-8
Molecular Formula:C₂₆H₃₇N₃O₄
Molecular Weight:455.597
Hs Code.:

Synonyms:(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

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Chemical Property of (2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

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Technology Process of (2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

There total 10 articles about (2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1067648-46-7
(2R,4S,5S)-5-azido-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

: 1067648-47-8
(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Guidance literature:: With water; triphenylphosphine; In methanol; at 20 ℃;
DOI:10.1016/j.ejmech.2009.11.013

Reference yield: 100.0%

: 1067648-47-8
(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Guidance literature:

Reference yield:

: 1067648-41-2
2,3-dideoxy-2-methyl-D-glucono-1,4-lactone

: 1067648-47-8
(2R,4S,5S)-5-amino-6-benzyloxy-4-hydroxy-2-methylhexanoic acid ((S)-1-benzylcarbamoyl-2-methylpropyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: di(n-butyl)tin oxide / toluene / 5 h / Reflux

1.2: 90 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / -15 - 0 °C

2.2: 0 - 20 °C

3.1: 2-hydroxypyridin; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 96 h / Reflux

4.1: water; triphenylphosphine / methanol / 20 °C

With 2-hydroxypyridin; di-isopropyl azodicarboxylate; water; di(n-butyl)tin oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.ejmech.2009.11.013