Technology Process of (1R,3S)-3-phenylcyclopentanamine
There total 3 articles about (1R,3S)-3-phenylcyclopentanamine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.17 h / 20 °C
2.1: ammonia / Raney Nickel / water; methanol / 32 h / 20 °C / 1551.49 Torr
3.1: Luna CN / hexane; ethanol
3.2: chiral OD-H column
With
hydroxylamine hydrochloride; ammonia; sodium acetate;
Raney Nickel;
In
methanol; ethanol; hexane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: ammonia / Raney Nickel / water; methanol / 32 h / 20 °C / 1551.49 Torr
2.1: Luna CN / hexane; ethanol
2.2: chiral OD-H column
With
ammonia;
Raney Nickel;
In
methanol; ethanol; hexane; water;
- Guidance literature:
-
With
8-formylquinoline; 2,6-di-tert-butyl-4-methylpyridine; palladium(II) trimethylacetate;
In
1,2-dichloro-ethane;
at 100 ℃;
for 48h;
Sealed tube;
Inert atmosphere;
DOI:10.1002/anie.201604268
