1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

Base Information

Chemical Name:1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea
CAS No.:1401074-35-8
Molecular Formula:C₂₂H₂₂FN₃O
Molecular Weight:363.435
Hs Code.:

Synonyms:1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

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Chemical Property of 1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

Chemical Property:

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Technology Process of 1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

There total 8 articles about 1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 59142-68-6
2-bromo-4-fluorobenzaldehyde

: 1401074-35-8
1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere; Cooling with ice; Sealed vessel

2: nitronium tetrafluoborate / sulfolane / 0.13 h / 35 - 71 °C / Inert atmosphere

3: hydrogen / methanol / 1 h / 20 °C / 1551.49 Torr / Sealed vessel; Inert atmosphere

4: pyridine / acetonitrile / 0.17 h / -10 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation

With pyridine; nitronium tetrafluoborate; hydrogen; potassium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In sulfolane; methanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1221445-04-0
2,2,2-trichloro-N-(6-fluoro-3-methylisoquinolin-5-yl)acetamide

: 1388846-21-6
(1R,3S)-3-phenylcyclopentanamine

: 1401074-35-8
1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 160678-59-1
(S)-3-(4-bromophenyl)cyclopentanone

: 1401074-35-8
1-(6-fluoro-3-methylisoquinolin-5-yl)-3-[(1R,3S)-3-phenylcyclopentyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 0.17 h / 20 °C

2.1: ammonia / Raney Nickel / water; methanol / 32 h / 20 °C / 1551.49 Torr

3.1: Luna CN / hexane; ethanol

3.2: chiral OD-H column

4.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation

With hydroxylamine hydrochloride; ammonia; sodium acetate; potassium carbonate; Raney Nickel; In methanol; ethanol; hexane; water; N,N-dimethyl-formamide;