(2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

Base Information

• Chemical Name: (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one
• CAS No.: 131726-68-6
• Molecular Formula: C₁₈H₁₉NO₄S
• Molecular Weight: 345.419

Synonyms:(2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

Chemical Property of (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

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Technology Process of (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

There total 2 articles about (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide (130973-53-4) → (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one (131726-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / NEt₃ / CH₂Cl₂ / 3 h / 0 °C

2: 1.) diethylboryl triflate, EtN(iPr)2 / 1.) CH₂Cl₂, hexane, -5 deg C, 0.5 h, 2.) -78 deg C, 20 min

With triethylamine; N-ethyl-N,N-diisopropylamine; diethylboron trifluoromethanesulfonate; In dichloromethane;

DOI:10.1016/S0040-4039(00)97794-3

Reference yield:

1-((R)-3-Methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-propan-1-one (131700-89-5) + benzaldehyde (100-52-7) → (2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one (131726-68-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; diethylboron trifluoromethanesulfonate; Yield given. Multistep reaction; 1.) CH₂Cl₂, hexane, -5 deg C, 0.5 h, 2.) -78 deg C, 20 min;

DOI:10.1016/S0040-4039(00)97794-3

Reference yield: 92.0%

(2R,3R)-3-Hydroxy-2-methyl-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ6-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one (131726-68-6) → (2R,3R)-(+)-3-hydroxy-2-methyl-3-phenylpropanoic acid (76549-04-7) + (R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide (130973-53-4)

Guidance literature:

With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)97794-3

upstream raw materials:

1-((R)-3-Methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-propan-1-one

benzaldehyde

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide

Downstream raw materials:

(2R,3R)-(+)-3-hydroxy-2-methyl-3-phenylpropanoic acid

(R)-3-methyl-2,3-dihydrobenzo[d]isothiazoline 1,1-dioxide

2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-ethanone

(S)-2-(Benzhydrylidene-amino)-1-((R)-3-methyl-1,1-dioxo-1,3-dihydro-1λ⁶-benzo[d]isothiazol-2-yl)-3-phenyl-propan-1-one

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