17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

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Chemical Name:17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate
CAS No.:544693-40-5
Molecular Formula:C₃₃H₃₈O₅S
Molecular Weight:546.728
Hs Code.:

Synonyms:17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

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Chemical Property of 17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

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Technology Process of 17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

There total 4 articles about 17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 104-15-4
toluene-4-sulfonic acid

: 544693-33-6
3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

: 544693-40-5
17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 24h;
DOI:10.1016/S0039-128X(02)00181-2

Reference yield:

: 858-98-0
3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 544693-40-5
17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98 percent / o-phenylenediamine / acetic acid / 3 h / 117 °C

2.1: 89 percent / NaOMe / benzene / 50 h / 6 °C

3.1: KBH₄ / methanol / 4 h / 20 °C

3.2: diphenyl-2-pyridylphosphine; imidazole; I₂ / CH₂Cl₂ / 24 h / 20 °C

3.3: 3.1 g / KOH / methanol / 3 h / Heating

4.1: 87 percent / CH₂Cl₂ / 24 h / 0 - 20 °C

With potassium borohydride; sodium methylate; 1,2-diamino-benzene; In methanol; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0039-128X(02)00181-2

Reference yield:

: 544693-34-7
3-benzyloxy-13α-estra-1,3,5(10)-trien-17-one

: 544693-40-5
17aα-hydroxy-3-benzyloxy-13α-D-homoestra-1,3,5(10)-trien-16α-yl-p-toluenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 89 percent / NaOMe / benzene / 50 h / 6 °C

2.1: KBH₄ / methanol / 4 h / 20 °C

2.2: diphenyl-2-pyridylphosphine; imidazole; I₂ / CH₂Cl₂ / 24 h / 20 °C

2.3: 3.1 g / KOH / methanol / 3 h / Heating

3.1: 87 percent / CH₂Cl₂ / 24 h / 0 - 20 °C

With potassium borohydride; sodium methylate; In methanol; dichloromethane; benzene;
DOI:10.1016/S0039-128X(02)00181-2