3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

Base Information

Chemical Name:3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde
CAS No.:544693-33-6
Molecular Formula:C₂₆H₃₀O₂
Molecular Weight:374.523
Hs Code.:

Synonyms:3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

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Chemical Property of 3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

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Technology Process of 3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

There total 3 articles about 3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 544693-35-8
(Z)-3-benzyloxy-16-hydroxymethylidene-13α-estra-1,3,5(10)-trien-17-one

: 544693-33-6
3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

: 3-benzyloxy-16-methylene-13α-estra-1,3,5(10)-16-trien-17β-ol

Guidance literature:: (Z)-3-benzyloxy-16-hydroxymethylidene-13α-estra-1,3,5(10)-trien-17-one; With potassium borohydride; In methanol; at 20 ℃; for 4h;

With 1H-imidazole; 2-(diphenylphosphino)pyridine; iodine; In dichloromethane; at 20 ℃; for 24h;

With potassium hydroxide; In methanol; for 3h; Heating;
DOI:10.1016/S0039-128X(02)00181-2

Reference yield:

: 858-98-0
3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one

: 544693-33-6
3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98 percent / o-phenylenediamine / acetic acid / 3 h / 117 °C

2.1: 89 percent / NaOMe / benzene / 50 h / 6 °C

3.1: KBH₄ / methanol / 4 h / 20 °C

3.2: diphenyl-2-pyridylphosphine; imidazole; I₂ / CH₂Cl₂ / 24 h / 20 °C

3.3: 3.1 g / KOH / methanol / 3 h / Heating

With potassium borohydride; sodium methylate; 1,2-diamino-benzene; In methanol; acetic acid; benzene;
DOI:10.1016/S0039-128X(02)00181-2

Reference yield:

: 544693-34-7
3-benzyloxy-13α-estra-1,3,5(10)-trien-17-one

: 544693-33-6
3-benzyloxy-14β-(prop-2-en-yl)-des-D-estra-1,3,5(10)-trien-13β-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / NaOMe / benzene / 50 h / 6 °C

2.1: KBH₄ / methanol / 4 h / 20 °C

2.2: diphenyl-2-pyridylphosphine; imidazole; I₂ / CH₂Cl₂ / 24 h / 20 °C

2.3: 3.1 g / KOH / methanol / 3 h / Heating

With potassium borohydride; sodium methylate; In methanol; benzene;
DOI:10.1016/S0039-128X(02)00181-2