Technology Process of 1-benzyl-3-cyano-1H-pyrrole-2-carbonyl azide
There total 2 articles about 1-benzyl-3-cyano-1H-pyrrole-2-carbonyl azide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diphenylphosphoranyl azide; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 6h;
DOI:10.1021/ol049207d
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 95 percent / KOH / ethanol / 1.5 h / Heating
2: diphenylphosphoryl azide; Et3N / dimethylformamide / 6 h / 20 °C
With
potassium hydroxide; diphenylphosphoranyl azide; triethylamine;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ol049207d
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 4.695 g / dimethylformamide; methanol / 8 h / 65 °C
2.1: 59 percent / KOH / ethane-1,2-diol / 1.5 h / 110 - 115 °C
3.1: tetrabutylammonium hydrogen sulfate / acetonitrile / 3 h / Heating
3.2: 56 percent / NH3 / methanol / 4 h / 60 °C
With
potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate;
In
methanol; ethylene glycol; N,N-dimethyl-formamide; acetonitrile;
1.1: Curtius rearrangement;
DOI:10.1021/ol049207d
