14052-84-7

Usage

InChI:InChI=1/C13H12N4/c14-12-11-6-7-17(13(11)16-9-15-12)8-10-4-2-1-3-5-10/h1-7,9H,8H2,(H2,14,15,16)

Upstream product

• 14036-06-7 diethoxymethyl acetate 
• 753478-33-0 2-amino-1-benzyl-3-cyanopyrrole 
• 54879-88-8 N-benzyl-2,2-dimethoxyethylamine 
• 100-44-7 benzyl chloride 
• 1500-85-2 7-deazaadenine 
• 753478-42-1 1-benzyl-2-benzyloxycarbonylamino-3-cyanopyrrole 
• 753478-40-9 1-benzyl-2-methoxycarbonylamino-3-cyanopyrrole 
• 753478-38-5 1-benzyl-3-cyano-1H-pyrrole-2-carbonyl azide 
• 100-52-7 benzaldehyde 
• 105788-28-1 1-benzyl-3-cyano-1H-pyrrole-2-carboxylic acid 

Downstream Products

• 1143505-17-2 7-benzyl-4-[(N,N-dimethylaminomethylidene)amino]-7H-pyrrolo[2,3-d]pyrimidine 

Relevant academic research and scientific papers

Direct C-H borylation and C-H arylation of pyrrolo2,3-dpyrimidines: Synthesis of 6,8-disubstituted 7-deazapurines

Novel direct C-H borylations of 7-deazapurines to position 8 by B 2pin2 under Ir catalysis were followed by Suzuki cross-couplings with aryl halides and other functional group transformations to give diverse 8-substituted 7-deazaaden

Facile synthesis of 1-substituted 2-amino-3-cyanopyrroles: New synthetic precursors for 5,6-unsubstituted pyrrolo[2,3-d]pyrimidines

(Equation Presented) 1-Benzyl-3-cyanopyrrole-2-carbonyl azide (5) underwent a Curtius rearrangement followed by quenching with alcohols to form the corresponding carbamates (6a-c). The carbamates 6a,b were unblocked to give the desired 2-amino-1-benzyl-3-cyanopyrrole (1a). A more facile procedure was subsequently developed for the synthesis of 1-substituted 2-amino-3- cyanopyrroles. N-Substituted aminoacetaldehyde dimethyl acetals (7a-c) were condensed with malononitrile in the presence of p-toluenesulfonic acid monohydrate to afford the corresponding 1-substituted 2-amino-3-cyanopyrroles (1a-c).