ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

Base Information

Chemical Name:ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate
CAS No.:250602-34-7
Molecular Formula:C₃₀H₃₂N₂O₅S
Molecular Weight:532.66
Hs Code.:

Synonyms:ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

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Chemical Property of ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

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Technology Process of ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

There total 7 articles about ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 202595-63-9
4-chloromethyl-5-methyl-2-thiophen-2-yl-oxazole

: 250602-95-0
ethyl (E)-6-[(4-hydroxybenzyloxy)imino]-6-phenylhexanoate

: 250602-34-7
ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 17h;
DOI:10.1248/cpb.51.138

Reference yield:

: 120743-99-9
p-[(tert-butyldimethylsilyl)oxy]benzaldehyde

: 250602-34-7
ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

Guidance literature:: Multi-step reaction with 6 steps

1: NaBH₄ / tetrahydrofuran; methanol / 0.5 h / 0 °C

2: 43 percent / DEAD; PPh₃ / 18 h / 20 °C

3: hydrazine monohydrate / tetrahydrofuran; ethanol / 1 h / 60 °C

4: acetic acid; sodium acetate / ethanol / 18 h / Heating

5: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / 20 °C

6: 95 percent / K₂CO₃ / dimethylformamide / 17 h / 20 °C

With sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium acetate; potassium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1248/cpb.51.138

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 250602-34-7
ethyl (E)-6-(4-{[5-methyl-2-(2-thienyl)-1,3-oxazol-4-yl]methoxy}benzyloxyimino)-6-phenylhexanoate

Guidance literature:: Multi-step reaction with 7 steps

1: imidazole / dimethylformamide / 1.5 h / 20 °C

2: NaBH₄ / tetrahydrofuran; methanol / 0.5 h / 0 °C

3: 43 percent / DEAD; PPh₃ / 18 h / 20 °C

4: hydrazine monohydrate / tetrahydrofuran; ethanol / 1 h / 60 °C

5: acetic acid; sodium acetate / ethanol / 18 h / Heating

6: tetrabutylammonium fluoride trihydrate / tetrahydrofuran / 1 h / 20 °C

7: 95 percent / K₂CO₃ / dimethylformamide / 17 h / 20 °C

With 1H-imidazole; sodium tetrahydroborate; tetrabutyl ammonium fluoride; sodium acetate; potassium carbonate; hydrazine hydrate; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; 3: Mitsunobu reaction;
DOI:10.1248/cpb.51.138