1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid

Base Information

• Chemical Name: 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid
• CAS No.: 102878-00-2
• Molecular Formula: C₁₀H₇Cl₂N₃O₂
• Molecular Weight: 272.09
• Mol file: 102878-00-2.mol

Synonyms:1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid

Chemical Property of 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid

There total 2 articles about 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-azido-2,5-dichlorobenzene (75458-15-0) + ethyl acetoacetate (141-97-9) → 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid (102878-00-2)

Guidance literature:

With sodium ethanolate; In ethanol; for 10h; Heating;

DOI:10.1002/jccs.200300173

Reference yield:

2,5 dichloroaniline (95-82-9) → 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid (102878-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaNO₂; aq. HCl / 0 - 5 °C

1.2: NaN₃

2.1: EtONa / ethanol

With hydrogenchloride; sodium ethanolate; sodium nitrite; In ethanol;

DOI:10.1002/jccs.200500015

Reference yield: 96.0%

1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carboxylic acid (102878-00-2) → 1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carbonyl chloride (740805-60-1)

Guidance literature:

With thionyl chloride; for 4h; Heating;

DOI:10.1002/jccs.200300173

upstream raw materials:

1-azido-2,5-dichlorobenzene

ethyl acetoacetate

2,5 dichloroaniline

Downstream raw materials:

1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carbonyl chloride

1-(2,5-dichlorophenyl)-5-methyl-1,2,3-triazol-4-carbonyl azide