[1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid

Base Information

• Chemical Name: [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid
• CAS No.: 381211-91-2
• Molecular Formula: C₃₅H₆₀O₅Si₂
• Molecular Weight: 617.029

Synonyms:[1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid

Chemical Property of [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid

Chemical Property:

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Technology Process of [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid

There total 2 articles about [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(tert-butoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene (381211-76-3) → [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid (381211-91-2)

Guidance literature:

With sodium hydroxide; sodium methylate; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2006.03.014

Reference yield:

C39H69NO4Si2 → [1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid (381211-91-2)

Guidance literature:

With sodium hydroxide; sodium methylate; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2006.03.014

Reference yield:

[1-(4-{2-[3,5-bis-(tert-butyldimethylsilanyloxy)-2-methylene-cyclohexylidene]ethylidene}-7a-methyl-3a,4,5,6,7,7a-hexahydro-3H-inden-1-yl)ethoxy]acetic acid (381211-91-2) + 2,4,4-trimethyl-2-pentanol (690-37-9) → 1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(1,1,3,3-tetramethylbutoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 15h;

upstream raw materials:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(tert-butoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

Downstream raw materials:

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(isopropoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

1α,3β-bis(tert-butyldimethylsilyloxy)-20(S)-(1-cyclopropyl-1-methylethoxycarbonylmethoxy)-9,10-secopregna-5,7,10(19),16-tetraene

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