3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide

Base Information

• Chemical Name: 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide
• CAS No.: 1235471-23-4
• Molecular Formula: C₁₉H₁₅F₃N₂O₂
• Molecular Weight: 360.336
• Mol file: 1235471-23-4.mol

Synonyms:3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide

Chemical Property of 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide

There total 6 articles about 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-trifluoromethylphenylamine (455-14-1) + C12H10ClNO2 → 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide (1235471-23-4)

Guidance literature:

With triethylamine; In toluene; at 20 ℃; Reflux;

DOI:10.1007/s00706-010-0265-9

Reference yield:

C14H15NO3 (1264294-04-3) → 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide (1235471-23-4)

Guidance literature:

Multi-step reaction with 3 steps

1: water; sodium hydroxide / ethanol

2: oxalyl dichloride / benzene

3: triethylamine / toluene / 20 °C / Reflux

With oxalyl dichloride; water; triethylamine; sodium hydroxide; In ethanol; toluene; benzene;

DOI:10.1007/s00706-010-0265-9

Reference yield:

C12H11NO3 (901927-10-4) → 3-(4-ethylphenyl)isoxazole-5-carboxylic acid (4-trifluoromethyl)phenylamide (1235471-23-4)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl dichloride / benzene

2: triethylamine / toluene / 20 °C / Reflux

With oxalyl dichloride; triethylamine; In toluene; benzene;

DOI:10.1007/s00706-010-0265-9

upstream raw materials:

4-trifluoromethylphenylamine

C₁₄H₁₅NO₃

C₁₂H₁₁NO₃

4-ethyl-N-hydroxybenzene-1-carboximidoyl chloride