5′-O-trityl-3′-O-phthalimidylthymidine

Base Information

Chemical Name:5′-O-trityl-3′-O-phthalimidylthymidine
CAS No.:103251-34-9
Molecular Formula:C₃₇H₃₁N₃O₇
Molecular Weight:629.669
Hs Code.:

Synonyms:5′-O-trityl-3′-O-phthalimidylthymidine

Suppliers and Price of 5′-O-trityl-3′-O-phthalimidylthymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5′-O-trityl-3′-O-phthalimidylthymidine

Chemical Property:

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Technology Process of 5′-O-trityl-3′-O-phthalimidylthymidine

There total 5 articles about 5′-O-trityl-3′-O-phthalimidylthymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 524-38-9
N-hydroxyphthalimide

: 55612-11-8
5'-O-trityldeoxyxylothymidine

: 103251-34-9
5′-O-trityl-3′-O-phthalimidylthymidine

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 15h;

Reference yield:

: 42214-24-4
1-(2-deoxy-3-O-methanesulfonyl-5-O-trityl-β-D-ribopentofuranosyl)thymine

: 103251-34-9
5′-O-trityl-3′-O-phthalimidylthymidine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide / 1,4-dioxane; water / 8 h

2: acetic acid / water

3: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 0 °C

With di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; 3: |Mitsunobu Displacement;
DOI:10.1515/hc-2015-0150

Reference yield:

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

: 103251-34-9
5′-O-trityl-3′-O-phthalimidylthymidine

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / 16 h / 20 - 40 °C

2: pyridine / 8 h

3: potassium hydroxide / 1,4-dioxane; water / 8 h

4: acetic acid / water

5: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 6 h / 0 °C

With pyridine; di-isopropyl azodicarboxylate; acetic acid; triphenylphosphine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; water; 5: |Mitsunobu Displacement;
DOI:10.1515/hc-2015-0150