C₃₅H₄₂N₆O₁₂S₂

Base Information

• Chemical Name: C₃₅H₄₂N₆O₁₂S₂
• CAS No.: 1510832-11-7
• Molecular Formula: C₃₅H₄₂N₆O₁₂S₂
• Molecular Weight: 802.883
• Mol file: 1510832-11-7.mol

Synonyms:C₃₅H₄₂N₆O₁₂S₂

Chemical Property of C₃₅H₄₂N₆O₁₂S₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₅H₄₂N₆O₁₂S₂

There total 7 articles about C₃₅H₄₂N₆O₁₂S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid (63088-78-8,448964-01-0,478409-64-2) → C35H42N6O12S2 (1510832-11-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / water; acetone / 23 - 30 °C / pH 10.2 - 10.7 / Inert atmosphere

2: 2-Nitrobenzenesulfonyl chloride; triethylamine / acetone; ethyl acetate / 20 - 28 °C / Inert atmosphere

3: tetrahydrofuran / 0.18 h / 72 °C / Inert atmosphere

4: dmap / tetrahydrofuran / 20 - 30 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl acetamide / 60 - 70 °C / Inert atmosphere

With dmap; potassium carbonate; 2-Nitrobenzenesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water; ethyl acetate; acetone;

DOI:10.1021/ol4031606

Reference yield:

N-4-nitrobenzene sulfonyl-O-benzylhydroxylamine (1033774-90-1) + tert-butyl 4-((2S,5S)-1-((2-nitrophenyl)sulfonyl)-5-(((2-nitrophenyl)sulfonyl)oxy)piperidine-2-carboxamido)piperidine-1-carboxylate (1510832-18-4) → C35H42N6O12S2 (1510832-11-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 60 - 70 ℃; Inert atmosphere;

DOI:10.1021/ol4031606

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → C35H42N6O12S2 (1510832-11-7)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydroxide / water; acetone / 23 - 30 °C / pH 10.2 - 10.7 / Inert atmosphere

2: 2-Nitrobenzenesulfonyl chloride; triethylamine / acetone; ethyl acetate / 20 - 28 °C / Inert atmosphere

3: tetrahydrofuran / 0.18 h / 72 °C / Inert atmosphere

4: dmap / tetrahydrofuran / 20 - 30 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl acetamide / 60 - 70 °C / Inert atmosphere

With dmap; potassium carbonate; 2-Nitrobenzenesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl acetamide; water; ethyl acetate; acetone;

DOI:10.1021/ol4031606

upstream raw materials:

N-4-nitrobenzene sulfonyl-O-benzylhydroxylamine

tert-butyl 4-((2S,5S)-1-((2-nitrophenyl)sulfonyl)-5-(((2-nitrophenyl)sulfonyl)oxy)piperidine-2-carboxamido)piperidine-1-carboxylate

(1S,4S)-5-((2-nitrophenyl)sulfonyl)-2-oxa-5-azabicyclo[2.2.2]octan-3-one

(2S,5R)-5-hydroxypiperidine-2-carboxylic acid

Downstream raw materials:

4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

tert-butyl 4-((1R,2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate

(2S,5R)-sulfuric acid mono{[(4-aminopiperidin-4-yl)carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl}ester

C₃₁H₄₂N₄O₈S₂