4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1510832-19-5
Molecular Formula:C₂₃H₃₆N₄O₄
Molecular Weight:432.563
Hs Code.:

Synonyms:4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Suppliers and Price of 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

There total 23 articles about 4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1171080-44-6
(2S,5R)-5-(benzyloxyamino)-piperidine-2-carboxylic acid benzyl ester

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1510832-19-5
4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With aluminum (III) chloride; In toluene; at 50 ℃; for 3h; Solvent; Reagent/catalyst;

Reference yield: 88.0%

: 1416134-47-8
(2S,5R)?5?[(benzyloxy)amino]piperidine?2?carboxylate

: 87120-72-7
1-(tert-butoxycarbonyl)-4-aminopiperidine

: 1510832-19-5
4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With aluminum (III) chloride; In toluene; at 50 ℃; for 10h;

Reference yield:

: 63088-78-8,448964-01-0,478409-64-2
(2S,5R)-5-hydroxypiperidine-2-carboxylic acid

: 1510832-19-5
4-((2S,5R)-((benzyloxy)amino)piperidine-2-carboxamido)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / water; acetone / 23 - 30 °C / pH 10.2 - 10.7 / Inert atmosphere

2: 2-Nitrobenzenesulfonyl chloride; triethylamine / acetone; ethyl acetate / 20 - 28 °C / Inert atmosphere

3: tetrahydrofuran / 0.18 h / 72 °C / Inert atmosphere

4: dmap / tetrahydrofuran / 20 - 30 °C / Inert atmosphere

5: potassium carbonate / N,N-dimethyl acetamide / 60 - 70 °C / Inert atmosphere

6: potassium carbonate; mercaptoacetic acid / methanol / 20 °C

With dmap; potassium carbonate; mercaptoacetic acid; 2-Nitrobenzenesulfonyl chloride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; ethyl acetate; acetone;
DOI:10.1021/ol4031606