N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Base Information

• Chemical Name: N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester
• CAS No.: 849599-82-2
• Molecular Formula: C₃₇H₅₀N₆O₉
• Molecular Weight: 722.839

Synonyms:N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Chemical Property of N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Chemical Property:

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Technology Process of N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

There total 4 articles about N-benzyloxycarbonyl-N^ε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Lys(Boc)-OH (2389-60-8) + (S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (728896-87-5) → N-benzyloxycarbonyl-Nε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (849599-82-2)

Guidance literature:

Z-Lys(Boc)-OH; With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole; In dichloromethane; N,N-dimethyl-formamide; at 0 ℃; for 0.166667h;

(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja045558b

Reference yield:

t-Boc-L-valine (13734-41-3) → N-benzyloxycarbonyl-Nε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (849599-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCTU; Cl-HOBt; 2,6-lutidine / CH₂Cl₂; dimethylformamide / 0.17 h / 0 °C

1.2: 52 percent / CH₂Cl₂; dimethylformamide

2.1: CF₃CO₂H / CH₂Cl₂

3.1: HCTU; Cl-HOBt; 2,6-lutidine / dimethylformamide; CH₂Cl₂ / 0.17 h / 0 °C

3.2: dimethylformamide; CH₂Cl₂

With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja045558b

Reference yield:

5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (625386-12-1) → N-benzyloxycarbonyl-Nε-(tert-butyloxycarbonyl)-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester (849599-82-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HCTU; Cl-HOBt; 2,6-lutidine / CH₂Cl₂; dimethylformamide / 0.17 h / 0 °C

1.2: 52 percent / CH₂Cl₂; dimethylformamide

2.1: CF₃CO₂H / CH₂Cl₂

3.1: HCTU; Cl-HOBt; 2,6-lutidine / dimethylformamide; CH₂Cl₂ / 0.17 h / 0 °C

3.2: dimethylformamide; CH₂Cl₂

With 2,6-dimethylpyridine; 6-chloro-3-((dimethylamino)(dimethyliminio)methyl)-1H-benzo[d][1,2,3]triazol-3-ium-1-olatehexafluorophosphate(V); 6-chloro-1-hydroxybenzotriazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/ja045558b

upstream raw materials:

Z-Lys(Boc)-OH

(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

t-Boc-L-valine

5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

Downstream raw materials:

5-(2-{6-tert-butoxycarbonylamino-2-[(2-(4-methoxy-benzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carbonyl)-amino]-hexanoylamino}-3-methyl-butyrylamino)-2-(4-methoxy-benzyl)-2H-pyrazole-3-carboxylic acid methyl ester

N^ε-tert-butyloxycarbonyl-(S)-lysinyl-(S)-valinyl-5-amino-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

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