(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

Base Information

Chemical Name:(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate
CAS No.:1609172-20-4
Molecular Formula:C₂₀H₂₀N₂O₄S
Molecular Weight:384.456
Hs Code.:

Synonyms:(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

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Technology Process of (E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

There total 3 articles about (E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 477872-36-9
1-(4-bromophenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1609172-20-4
(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: With palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 80 ℃; Inert atmosphere;
DOI:10.1021/jm401899x

Reference yield:

: 271-63-6
7-Azaindole

: 1609172-20-4
(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm401899x

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1609172-20-4
(E)-tert-butyl 3-(4-(1H-pyrrolo[2,3-b]pyridin-1-ylsulfonyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 20 °C / Inert atmosphere

2: triethylamine; triphenylphosphine; palladium diacetate; sodium hydrogencarbonate / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

With tetra(n-butyl)ammonium hydrogensulfate; palladium diacetate; sodium hydrogencarbonate; triethylamine; triphenylphosphine; potassium hydroxide; In dichloromethane; N,N-dimethyl-formamide; 2: |Heck Reaction;
DOI:10.1021/jm401899x