2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

Base Information

Chemical Name:2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole
CAS No.:1431423-76-5
Molecular Formula:C₂₂H₁₂F₆N₄O
Molecular Weight:462.354
Hs Code.:

Synonyms:2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

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Chemical Property of 2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

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Technology Process of 2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

There total 5 articles about 2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1431423-78-7
2-[6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

: 100-39-0
benzyl bromide

: 1431423-76-5
2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 71056-61-6
ethyl 7-amino-1H-indole-2-carboxylate

: 1431423-76-5
2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: acetic acid / 3 h / 110 °C / Sealed tube

2: hydrazine / ethanol / 20 h / 120 °C / Inert atmosphere; Reflux

3: toluene-4-sulfonic acid / 1 h / 80 °C / Inert atmosphere

4: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; acetic acid; hydrazine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1431426-38-8
ethyl 6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinoline-2-carboxylate

: 1431423-76-5
2-[1-benzyl-6,8-bis(trifluoromethyl)-1H-pyrrolo[3,2-h]quinolin-2-yl]-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine / ethanol / 20 h / 120 °C / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / 1 h / 80 °C / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

With potassium carbonate; toluene-4-sulfonic acid; hydrazine; In ethanol; N,N-dimethyl-formamide;