3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)

Base Information

• Chemical Name: 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)
• CAS No.: 749245-13-4
• Molecular Formula: C₃₈H₆₂O₅Si₂
• Molecular Weight: 655.078
• Mol file: 749245-13-4.mol

Synonyms:3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)

Chemical Property of 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)

There total 1 articles about 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-carboethoxymethylbenzylzinc(II) bromide (749245-79-2) + (3R, 4R)-2-methylene-3-[(3S)-3-(tert-butyldimethylsiloxy)-3-cyclohexylprop-1-ynyl]-4-(tert-butyldimethylsiloxy)cyclopentane-1-one (134005-63-3) → 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE1 ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether) (749245-13-4)

Guidance literature:

3-carboethoxymethylbenzylzinc(II) bromide; With copper(I) cyanide*2 lithium chloride; In tetrahydrofuran; at -70 ℃; for 0.333333h;

(3R, 4R)-2-methylene-3-[(3S)-3-(tert-butyldimethylsiloxy)-3-cyclohexylprop-1-ynyl]-4-(tert-butyldimethylsiloxy)cyclopentane-1-one; With chloro-trimethyl-silane; In tetrahydrofuran; diethyl ether; at -70 - 0 ℃; for 1h;

With pyridinium p-toluenesulfonate; In diethyl ether; isopropyl alcohol; at 20 ℃; for 12h;

Reference yield:

3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE1 ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether) (749245-13-4) → 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGF1α ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether) (749245-14-5) + 3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGF1β ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether) (749245-15-6)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; diisobutylaluminium hydride; In hexane; toluene; at -78 - -10 ℃; for 1h;

3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGE₁ ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether); In hexane; toluene; at -78 - -25 ℃; for 1h;

upstream raw materials:

3-carboethoxymethylbenzylzinc(II) bromide

(3R, 4R)-2-methylene-3-[(3S)-3-(tert-butyldimethylsiloxy)-3-cyclohexylprop-1-ynyl]-4-(tert-butyldimethylsiloxy)cyclopentane-1-one

Downstream raw materials:

3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGF1α ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)

3, 4, 5, 16, 17, 18, 19, 20-octanol-2, 6-inter-m-phenylene-15-cyclohexyl-13, 14-didehydro-PGF1β ethyl ester 11, 15-bis(tert-butyldimethylsilyl ether)