3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Base Information

Chemical Name:3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide
CAS No.:830324-70-4
Molecular Formula:C₂₃H₁₃ClF₆N₄O₂
Molecular Weight:526.825
Hs Code.:

Synonyms:3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

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Chemical Property of 3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

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Technology Process of 3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

There total 4 articles about 3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 830324-69-1
3,4-dihydro-4-oxo-3-(2-chloro-3-pyridyl)-2-quinazolinecarbothioic acid S-p-tolyl ester

: 830324-70-4
3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: With silver trifluoroacetate; In tetrahydrofuran; toluene; at 60 ℃;
DOI:10.1055/s-2004-834805

Reference yield:

: 956-30-9
2-amino-N-(2-chloropyridin-3-yl)benzamide

: 830324-70-4
3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / pyridine / tetrahydrofuran / 0.25 h / 0 °C

2: 100 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

3: 87 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

4: 100 percent / AgOCOCF₃ / tetrahydrofuran; toluene / 1.5 h / 60 °C

With pyridine; chloro-trimethyl-silane; trimethylaluminum; silver trifluoroacetate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.tet.2005.02.038

Reference yield:

: 830324-66-8
N-[2-(2-chloro-3-pyridyl)carbamoylphenyl]oxalamic acid ethyl ester

: 830324-70-4
3-(2-chloro-pyridin-3-yl)-4-oxo-3,4-dihydro-quinazoline-2-carboxylic acid 3,5-bis-trifluoromethyl-benzylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N; trimethylsilyl chloride / 1,2-dichloro-ethane / 1.5 h / 80 °C

2: 87 percent / AlMe₃ / CH₂Cl₂; hexane / 0 - 20 °C

3: 100 percent / AgOCOCF₃ / tetrahydrofuran; toluene / 1.5 h / 60 °C

With chloro-trimethyl-silane; trimethylaluminum; silver trifluoroacetate; triethylamine; In tetrahydrofuran; hexane; dichloromethane; 1,2-dichloro-ethane; toluene;
DOI:10.1016/j.tet.2005.02.038