(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

Base Information

Chemical Name:(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate
CAS No.:1574543-45-5
Molecular Formula:C₂₂H₂₇NO₄
Molecular Weight:369.461
Hs Code.:

Synonyms:(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

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Technology Process of (R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

There total 3 articles about (R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 14055-37-9
2-(cyclopent-3-en-1-yl)acetaldehyde

: 1574543-42-2
(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 2-diazoacetate

: 1574543-45-5
(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

Guidance literature:: With boron trifluoride diethyl etherate; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol5002973

Reference yield:

: 1574543-67-1
(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 2-bromoacetate

: 1574543-45-5
(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

2: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With N,N'-ditosylhydrazine; boron trifluoride diethyl etherate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1021/ol5002973

Reference yield:

: 125416-37-7
(R)-mandelic acid piperidine amide

: 1574543-45-5
(R)-2-oxo-1-phenyl-2-(piperidin-1-yl)ethyl 4-(cyclopent-3-enyl)-3-oxobutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

2: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0.5 h / 0 °C / Inert atmosphere

3: boron trifluoride diethyl etherate / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With N,N'-ditosylhydrazine; boron trifluoride diethyl etherate; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1021/ol5002973