6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

Base Information

Chemical Name:6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide
CAS No.:1070294-15-3
Molecular Formula:C₃₂H₃₃N₅O₃
Molecular Weight:535.646
Hs Code.:

Synonyms:6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

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Chemical Property of 6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

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Technology Process of 6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

There total 9 articles about 6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1070294-17-5
4-{[6-(5-cyclopropylcarbamoyl-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carbonyl]amino}piperidine-1-carboxylic acid tert-butyl ester

: 1070294-15-3
6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

Guidance literature:: 4-{[6-(5-cyclopropylcarbamoyl-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carbonyl]amino}piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

With ammonia; In dichloromethane; water;

Reference yield:

: 3731-53-1
4-(aminomethyl)pyridine

: 1070294-15-3
6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 24 h / Heating / reflux

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 40 h / 80 °C

3: sodium hydroxide; water / methanol / 6 h / 50 °C

4: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 3 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With sodium hydroxide; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1070293-47-8
(E)-6-bromo-4-(methoxymethylene)isochroman-1,3-dione

: 1070294-15-3
6-(5-(cyclopropylcarbamoyl)-2-methylphenyl)-1-oxo-2-pyridin-4-ylmethyl-1,2-dihydroisoquinoline-4-carboxylic acid piperidin-4-ylamide

Guidance literature:: Multi-step reaction with 6 steps

1: methanol; sulfuric acid / 19 h / Heating / reflux

2: methanol / 24 h / Heating / reflux

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 40 h / 80 °C

4: sodium hydroxide; water / methanol / 6 h / 50 °C

5: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 3 h / 20 °C

6: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With methanol; sodium hydroxide; sulfuric acid; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;