1-(3-Ethoxyphenyl)-piperazine dihydrochloride

Base Information

• Chemical Name: 1-(3-Ethoxyphenyl)-piperazine dihydrochloride
• CAS No.: 89989-06-0
• Molecular Formula: C₁₂H₁₈N₂O
• Molecular Weight: 206.288
• Mol file: 89989-06-0.mol

Synonyms:1-(3-Ethoxyphenyl)piperazine;1-(m-Ethoxyphenyl)piperazine

Chemical Property of 1-(3-Ethoxyphenyl)-piperazine dihydrochloride

Chemical Property:

• PSA: 24.50000
• LogP: 3.49270

Purity/Quality:

97% ^*data from raw suppliers

1-(3-Ethoxy-phenyl)-piperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(3-Ethoxyphenyl)-piperazine dihydrochloride

There total 3 articles about 1-(3-Ethoxyphenyl)-piperazine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzyloxy)-3-iodobenzene (107623-21-2) → 1-(3-ethoxyphenyl)piperazine (89989-06-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 72 h / 80 °C / Inert atmosphere

2.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol; ethyl acetate / 48 h / 2068.65 Torr

3.1: potassium carbonate / acetone / 13 h / Reflux

3.2: 1 h / 0 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In methanol; ethyl acetate; acetone; toluene;

Reference yield:

1,1-dimethylethyl 4-[3-(phenylmethoxy)phenyl]-1-piperazinecarboxylate → 1-(3-ethoxyphenyl)piperazine (89989-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol; ethyl acetate / 48 h / 2068.65 Torr

2.1: potassium carbonate / acetone / 13 h / Reflux

2.2: 1 h / 0 °C

With 10 wt% Pd(OH)2 on carbon; hydrogen; potassium carbonate; In methanol; ethyl acetate; acetone;

Reference yield:

→ 1-(3-ethoxyphenyl)piperazine (89989-06-0)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium t-butanolate; In toluene; at 100 - 110 ℃; Inert atmosphere;

upstream raw materials:

1-(benzyloxy)-3-iodobenzene