Technology Process of (R)-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one
There total 11 articles about (R)-6-ethyl-6-(p-tolyl)benzo[b]pyrrolo[1,2-d][1,4]oxazepin-7(6H)-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorus pentachloride;
In
dichloromethane;
at 35 ℃;
for 15h;
stereoselective reaction;
DOI:10.1016/j.tetlet.2013.07.115
- Guidance literature:
-
Multi-step reaction with 9 steps
1: titanium(IV) isopropylate / toluene / 12 h / 100 °C
2: zinc(II) chloride / diethyl ether / -78 - 25 °C
3: potassium hydroxide; water / methanol / Reflux
4: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
5: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C
6: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux
7: sodium nitrite; sodium hydrogen sulfate; acetic acid / ethanol / 3 h / 20 °C
8: sodium hydroxide; ethanol / tetrahydrofuran / 5 h / Reflux
9: phosphorus pentachloride / dichloromethane / 15 h / 35 °C
With
titanium(IV) isopropylate; sodium hydrogen sulfate; 15-crown-5; tin(II) chloride dihdyrate; ethanol; phosphorus pentachloride; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; zinc(II) chloride; sodium nitrite;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetlet.2013.07.115
- Guidance literature:
-
Multi-step reaction with 10 steps
1: aluminum (III) chloride / 1,2-dichloro-ethane / 4 h / 0 - 30 °C
2: titanium(IV) isopropylate / toluene / 12 h / 100 °C
3: zinc(II) chloride / diethyl ether / -78 - 25 °C
4: potassium hydroxide; water / methanol / Reflux
5: potassium carbonate / N,N-dimethyl-formamide / 4 h / 25 °C
6: sodium hydride; 15-crown-5 / tetrahydrofuran / 17 h / 0 - 20 °C
7: tin(II) chloride dihdyrate / ethanol / 5 h / Reflux
8: sodium nitrite; sodium hydrogen sulfate; acetic acid / ethanol / 3 h / 20 °C
9: sodium hydroxide; ethanol / tetrahydrofuran / 5 h / Reflux
10: phosphorus pentachloride / dichloromethane / 15 h / 35 °C
With
titanium(IV) isopropylate; aluminum (III) chloride; sodium hydrogen sulfate; 15-crown-5; tin(II) chloride dihdyrate; ethanol; phosphorus pentachloride; water; sodium hydride; potassium carbonate; acetic acid; potassium hydroxide; sodium hydroxide; zinc(II) chloride; sodium nitrite;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
1: |Friedel-Crafts Acylation;
DOI:10.1016/j.tetlet.2013.07.115
