METHYL 2-N-BOC-2-AMINOMETHYL-3-(4-CHLORO-PHENYL)-PROPIONATE

Base Information

• Chemical Name: METHYL 2-N-BOC-2-AMINOMETHYL-3-(4-CHLORO-PHENYL)-PROPIONATE
• CAS No.: 886366-43-4
• Molecular Formula: C16H22 Cl N O4
• Molecular Weight: 327.808
• Hs Code.: 2924299090
• Mol file: 886366-43-4.mol

Synonyms:2-(tert-butoxycarbonylamino-methyl)-3-(4-chloro-phenyl)-propionic acid methyl ester;Methyl 3-((tert-butoxycarbonyl)amino)-2-(4-chlorobenzyl)propanoate;Methyl 2-N-Boc-2-aminomethyl-3-(4-chloro-phenyl);Methyl 2-N-Boc-2-aminomethyl-3-(4-chloro-phenyl)-propionate;A-2217;

Chemical Property of METHYL 2-N-BOC-2-AMINOMETHYL-3-(4-CHLORO-PHENYL)-PROPIONATE

Chemical Property:

• Vapor Pressure: 1.68E-09mmHg at 25°C
• Refractive Index: 1.534
• Boiling Point: 466.5°C at 760 mmHg
• Flash Point: 235.9°C
• PSA: 64.63000
• Density: 1.22g/cm³
• LogP: 3.58730
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-((tert-butoxycarbonyl)amino)-2-(4-chlorobenzyl)propanoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 2-N-BOC-2-AMINOMETHYL-3-(4-CHLORO-PHENYL)-PROPIONATE

There total 1 articles about METHYL 2-N-BOC-2-AMINOMETHYL-3-(4-CHLORO-PHENYL)-PROPIONATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

3-[(4-chlorophenyl)methyl]-4-methoxy-4-oxobutanoic acid (1172066-15-7) + tert-butyl alcohol (75-65-0) → methyl 3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoate (886366-43-4)

Guidance literature:

With diphenyl phosphoryl azide; triethylamine; for 6h; Reflux;

Reference yield: 85.0%

methyl 3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoate (886366-43-4) → 3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoic acid (626220-65-3)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 3h;

upstream raw materials:

3-[(4-chlorophenyl)methyl]-4-methoxy-4-oxobutanoic acid

tert-butyl alcohol

Downstream raw materials:

3-(tert-butoxycarbonylamino)-2-(4-chlorobenzyl)propanoic acid