2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid

Base Information

• Chemical Name: 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid
• CAS No.: 71402-67-0
• Molecular Formula: C₁₆H₁₅NO₃
• Molecular Weight: 269.3
• Mol file: 71402-67-0.mol

Synonyms:2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid

Chemical Property of 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid

There total 3 articles about 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

homophthalic anhydride (703-59-3) + benzylamine (100-46-9) → 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid (71402-67-0)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h; Temperature;

DOI:10.1021/acs.joc.1c01163

Reference yield: 70.0%

homophthalic anhydride (703-59-3) + N-(1-methyl-1H-pyrrol-2-yl-methylidene)-benzylamine → 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid (71402-67-0) + 2-[1-[(benzylamino)carbonyl]-2-(1-methyl-1H-pyrrol-2-yl)ethenyl]benzenecarboxylic acid + (+/-)-trans-2-benzyl-3-(1-methyl-1H-pyrrol-2-yl)-1-oxo-1,2,3,4-tetrahydro-4-isoquinoline carboxylic acid

Guidance literature:

In benzene; for 0.25h; Heating;

DOI:10.1002/jhet.5570390134

Reference yield: 9.0%

(E)-N-benzyl-1-(furan-2-yl)methanimine (4393-11-7) + homophthalic anhydride (703-59-3) → (+/-)-trans-2-benzyl-3-(furan-2-yl)-1-oxo-1,2,3,4-tetrahydro-4-isoquinoline carboxylic acid + (+/-)-cis-2-benzyl-3-(furan-2-yl)-1-oxo-1,2,3,4-tetrahydro-4-isoquinoline carboxylic acid + 2-[2-(benzylamino)-2-oxoethyl]benzenecarboxylic acid (71402-67-0) + 4-(furan-2-yl)methylidene-1H-isochromene-1,3-dione (21401-69-4)

Guidance literature:

In 1,2-dichloro-ethane; at 83 ℃; for 0.75h; Further Variations:; Solvents; Temperatures; Product distribution;

DOI:10.3390/11060403

upstream raw materials:

homophthalic anhydride

(E)-N-benzyl-1-(furan-2-yl)methanimine

benzylamine