Technology Process of (E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide
There total 9 articles about (E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
for 3h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere
2.2: -40 - 20 °C
3.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere
4.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere
4.2: 1 h / 30 °C
4.3: 30 °C
5.1: dichloromethane / 20 °C
6.1: trifluoroacetic acid / dichloromethane / 3 h
With
water; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; lithium hexamethyldisilazane;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere
2.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere
2.2: 1 h / 30 °C
2.3: 30 °C
3.1: dichloromethane / 20 °C
4.1: trifluoroacetic acid / dichloromethane / 3 h
With
water; iron; ammonium chloride; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; water;
