(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

Base Information

Chemical Name:(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide
CAS No.:1422828-06-5
Molecular Formula:C₁₈H₂₀IN₇O
Molecular Weight:477.308
Hs Code.:

Synonyms:(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

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Chemical Property of (E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

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Technology Process of (E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

There total 9 articles about (E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422828-05-4
C₂₃H₂₈IN₇O₃

: 1422828-06-5
(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 3h;

Reference yield:

: 350-46-9,178603-76-4
4-Fluoronitrobenzene

: 1422828-06-5
(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 100 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -40 °C / Inert atmosphere

2.2: -40 - 20 °C

3.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere

4.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere

4.2: 1 h / 30 °C

4.3: 30 °C

5.1: dichloromethane / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 3 h

With water; iron; potassium carbonate; ammonium chloride; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1422828-02-1
tert-butyl 3-iodo-1-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-ylcarbamate

: 1422828-06-5
(E)-N-(4-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenyl)-4-(dimethylamino)-N-methylbut-2-enamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: water; iron; ammonium chloride / tetrahydrofuran; ethanol / 2 h / 50 °C / Inert atmosphere

2.1: tetrahydrofuran; water / 4 h / 30 °C / Inert atmosphere

2.2: 1 h / 30 °C

2.3: 30 °C

3.1: dichloromethane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h

With water; iron; ammonium chloride; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;