2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Base Information

Chemical Name:2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester
CAS No.:873310-64-6
Molecular Formula:C₂₅H₃₅NO₇
Molecular Weight:461.555
Hs Code.:

Synonyms:2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Suppliers and Price of 2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

There total 2 articles about 2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 541-16-2
t-butyl malonate

: 133464-37-6
(4R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester

: 873310-64-6
2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Guidance literature:: t-butyl malonate; With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

(4R)-4-formyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 18h;
DOI:10.1016/j.tetlet.2005.10.121

Reference yield:

: 133464-36-5
(S)-hydroxymethyl-2,2-dimethyloxazolidine-3-carboxylic acid benzyl ester

: 873310-64-6
2S-(3-benzyloxycarbonyl-2,2-dimethyloxazolidin-4-ylmethylene)-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / (COCl)2; DMSO; Et₃N / CH₂Cl₂ / -78 °C

2.1: LDA; HMPA / tetrahydrofuran / -78 °C

2.2: 80 percent / Ac₂O; DMAP; pyridine

With N,N,N,N,N,N-hexamethylphosphoric triamide; oxalyl dichloride; dimethyl sulfoxide; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; 1.1: Swern oxidation;
DOI:10.1021/jo061037q