2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

Base Information

Chemical Name:2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel
CAS No.:601473-00-1
Molecular Formula:C₅₆H₉₃NO₁₂Si₃
Molecular Weight:1056.61
Hs Code.:

Synonyms:2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

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Chemical Property of 2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

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Technology Process of 2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

There total 1 articles about 2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1119-60-4
hept-6-enoic acid

: 521087-16-1
2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

: 601473-00-1
2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1021/jm030770w

Reference yield: 79.0%

: 1577-22-6
5-hexenoic acid

: 601473-00-1
2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

: 601472-98-4
2-debenzoyl-2-hex-5-enoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In toluene; at 60 ℃; for 3.5h;
DOI:10.1021/jm030770w

Reference yield:

: 601473-00-1
2-debenzoyl-2'-O-tert-butyldimethylsilyl-3'-de-tert-butoxycarbonyl-3'-hept-6-enoyl-7,10-ditriethylsilyldocetaxel

: C₄₄H₆₃NO₁₃

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / DCC; DMAP / toluene / 3.5 h / 60 °C

2: 70 percent / H₂ / Pd/C / ethyl acetate / 3.5 h / 20 °C

3: 65 percent / pyridine; HF / acetonitrile / 7.5 h / 0 - 20 °C

With pyridine; dmap; hydrogen fluoride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethyl acetate; toluene; acetonitrile;
DOI:10.1021/jm030770w