2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Base Information

Chemical Name:2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel
CAS No.:521087-16-1
Molecular Formula:C₄₉H₈₃NO₁₁Si₃
Molecular Weight:946.455
Hs Code.:

Synonyms:2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

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Chemical Property of 2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

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Technology Process of 2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

There total 6 articles about 2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 521087-18-3
2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

: 521087-16-1
2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1002/ejoc.200390092

Reference yield:

: 994-30-9
triethylsilyl chloride

: 521087-16-1
2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / imidazole / acetonitrile; CH₂Cl₂ / 1.5 h / 60 °C

2: 54 percent / Red-Al / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/ejoc.200390092

Reference yield:

: 114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0
Docetaxel

: 521087-16-1
2-debenzoyl-2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: 87 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 0.75 h / 0 °C

3: 58 percent / imidazole / acetonitrile; CH₂Cl₂ / 1.5 h / 60 °C

4: 54 percent / Red-Al / tetrahydrofuran / 0.5 h / 0 °C

With 1H-imidazole; sodium bis(2-methoxyethoxy)aluminium dihydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200390092