4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Base Information

Chemical Name:4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one
CAS No.:1446235-73-9
Molecular Formula:C₂₂H₂₀FN₃O₃S
Molecular Weight:425.484
Hs Code.:

Synonyms:4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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Chemical Property of 4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

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Technology Process of 4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

There total 18 articles about 4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 4-(2-((4-fluorophenyl)amino)-5-((methylsulfonyl)methyl)phenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one

: 1446235-73-9
4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: With cetyltrimethylammonim bromide; potassium hydroxide; In 1,4-dioxane; water; at 90 ℃; for 2.5h;

Reference yield:

: 213627-30-6
1-bromo-4-((methylsulfonyl)methyl)benzene

: 1446235-73-9
4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: XPhos; palladium diacetate; caesium carbonate / toluene; tert-butyl alcohol / 0.25 h / 150 °C / Microwave irradiation

2: acetic acid; N-Bromosuccinimide / 1.5 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; sodium carbonate / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

4: cetyltrimethylammonim bromide; potassium hydroxide / 1,4-dioxane; water / 2.5 h / 90 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; cetyltrimethylammonim bromide; palladium diacetate; sodium carbonate; caesium carbonate; acetic acid; potassium hydroxide; XPhos; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane; water; toluene; tert-butyl alcohol;

Reference yield:

: 2-bromo-N-(4-fluorophenyl)-4-((methylsulfonyl)methyl)aniline

: 1446235-73-9
4-{2-[(4-fluorophenyl)amino]-5-[(methylsulfonyl)methyl]phenyl}-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

Guidance literature:: Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; sodium carbonate / 1,4-dioxane; water / 3 h / 60 °C / Inert atmosphere

2: cetyltrimethylammonim bromide; potassium hydroxide / 1,4-dioxane; water / 2.5 h / 90 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; cetyltrimethylammonim bromide; sodium carbonate; potassium hydroxide; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane; In 1,4-dioxane; water;