(-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

Base Information

• Chemical Name: (-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine
• CAS No.: 1365246-85-0
• Molecular Formula: C₃₅H₄₂FN₃O₅SSi
• Molecular Weight: 663.885

Synonyms:(-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

Chemical Property of (-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

There total 3 articles about (-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-amino-1-((2R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one (1365246-84-9) + 4,4'-dimethoxytrityl chloride (40615-36-9) → (-)-5'-O-(t-butyldimethylsilyl)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine (1365246-85-0)

Guidance literature:

With pyridine; at 0 - 20 ℃;

DOI:10.1021/jm201551m

Reference yield:

emtricitabine (143491-57-0,144371-00-6,145213-48-5,145986-26-1) → (-)-5'-O-(t-butyldimethylsilyl)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine (1365246-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

2: pyridine / 0 - 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jm201551m

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → (-)-5'-O-(t-butyldimethylsilyl)-N4-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine (1365246-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 18 h / 20 °C

2: pyridine / 0 - 20 °C

With pyridine; 1H-imidazole; In N,N-dimethyl-formamide;

DOI:10.1021/jm201551m

upstream raw materials:

4-amino-1-((2R,5S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-1,3-oxathiolan-5-yl)-5-fluoropyrimidin-2(1H)-one

4,4'-dimethoxytrityl chloride

tert-butyldimethylsilyl chloride

emtricitabine

Downstream raw materials:

(-)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

C₅₈H₇₂F₂N₆O₁₂S

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1365246-85-0 (-)-5'-O-(t-butyldimethylsilyl)-N₄-(4,4'-dimethoxytrityl)-5-fluoro-2',3'-dideoxy-3'-thiacytidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send