2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

Base Information

Chemical Name:2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide
CAS No.:257875-28-8
Molecular Formula:C₃₅H₄₆N₂O₄Si
Molecular Weight:586.847
Hs Code.:

Synonyms:2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

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Chemical Property of 2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

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Technology Process of 2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

There total 4 articles about 2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 908338-26-1
Methanesulfonic acid (S)-4,4-diethoxy-2-hydroxymethyl-butyl ester

: 257875-28-8
2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.11 g / imidazole / dimethylformamide / 0 - 20 °C

2: NaH; NaI / dimethylformamide

With 1H-imidazole; sodium hydride; sodium iodide; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.033

Reference yield:

: 144461-19-8,134665-24-0
(R)-2-(2,2-diethoxyethyl)-1,3-propanediol monoacetate

: 257875-28-8
2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.53 g / triethylamine / tetrahydrofuran / 0.42 h / 0 °C

2: 1.31 g / NaOH / dioxane; H₂O / 1 h / 0 °C

3: 2.11 g / imidazole / dimethylformamide / 0 - 20 °C

4: NaH; NaI / dimethylformamide

With 1H-imidazole; sodium hydroxide; sodium hydride; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.033

Reference yield:

: 134665-15-9
(S)-2-(acetoxymethyl)-4,4-diethoxybutyl methanesulfonate

: 257875-28-8
2-{1-[(S)-2-(tert-butyldiphenylsilyloxymethyl)-4,4-diethoxybutyl]-1H-indol-3-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.31 g / NaOH / dioxane; H₂O / 1 h / 0 °C

2: 2.11 g / imidazole / dimethylformamide / 0 - 20 °C

3: NaH; NaI / dimethylformamide

With 1H-imidazole; sodium hydroxide; sodium hydride; sodium iodide; In 1,4-dioxane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.05.033