2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Base Information

Chemical Name:2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide
CAS No.:1428790-04-8
Molecular Formula:C₂₃H₂₉F₄N₅O₃S
Molecular Weight:531.575
Hs Code.:

Synonyms:2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Chemical Property of 2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

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Technology Process of 2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

There total 10 articles about 2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428790-41-3
tert-butyl N-(2-fluoro-4-(1-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methylamino)-1-oxopropan-2-yl)benzyl)sulfamoylcarbamate

: 1428790-04-8
2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 4h;

Reference yield:

: 78543-07-4
ethyl 2-(3-fluoro-4-nitrophenyl)propionate

: 1428790-04-8
2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 6 h

2.1: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / acetonitrile / 4.17 h / 10 - 20 °C

3.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

5.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

6.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

6.2: 2 h

7.1: triethylamine / dichloromethane / 15 h / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; palladium 10% on activated carbon; p-toluenesulfonic acid monohydrate; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 95037-98-2
ethyl 2-(4-amino-3-fluorophenyl)propionate

: 1428790-04-8
2-(3-fluoro-4-((sulfamoylamino)methyl)phenyl)-N-((2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)pyridin-3-yl)methyl)propanamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium nitrite; potassium iodide; p-toluenesulfonic acid monohydrate / acetonitrile / 4.17 h / 10 - 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 1,1'-bis-(diphenylphosphino)ferrocene; 5-(N,N-dimethyl)amiloride hydrochloride / 15 h / 120 °C / Inert atmosphere

3.1: sodium hydroxide / tetrahydrofuran; water / 15 h / 20 °C

4.1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; benzotriazol-1-ol; triethylamine / 20 °C

5.1: nickel(II) chloride hexahydrate / ethanol / 0.25 h

5.2: 2 h

6.1: triethylamine / dichloromethane / 15 h / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel(II) chloride hexahydrate; p-toluenesulfonic acid monohydrate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; trifluoroacetic acid; potassium iodide; sodium hydroxide; 5-(N,N-dimethyl)amiloride hydrochloride; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;